Peptide drug Botox 100u/vial CAS: 93384-43-1

Botox's main ingredient is high-purity botulinum toxin type A, and its development originated from 19th-century research on botulism.

18th-century European sausage poisoning incidents first drew scientists' attention to the toxins secreted by Clostridium botulinum;

In 1895, a Belgian microbiologist isolated Clostridium botulinum;

Botulinum toxin was first extracted in 1920;

In 1928, the initial purification of botulinum toxin type A was completed.

In the 1940s, American scientists improved the botulinum toxin purification technology, initially planning for military use, but later shifting to medical applications-in 1978, it was used to treat strabismus;

in 1989, it was used to treat blepharospasm and other abnormal muscle contractions.

In 1987, a Canadian ophthalmologist accidentally discovered its ability to reduce frown lines, propelling its entry into the cosmetic field.

In 1992, related research was published, and Allergan named it Botox.

In 2002, it received FDA approval for wrinkle removal, becoming the world's first cosmetic botulinum toxin formulation. Currently, it is widely used in the medical and cosmetic fields, is a prescription drug, and must be used under the guidance of a professional physician.

 Core Ingredient: High-purity type A botulinum toxin, commonly available in 50U, 100U, and 200U vials, meeting the standards of various pharmacopoeias, with stable efficacy and no significant interference from impurities.

- Dosage Form and Specifications: Primarily lyophilized powder for injection, each box contains one vial of lyophilized powder and one vial of accompanying saline solution; some boxes contain 5 vials. The lyophilized powder is a white, loose powder that dissolves into a colorless, clear liquid free of impurities.

- Auxiliary Ingredients: Albumin and lactose are added to the lyophilized powder to stabilize toxin activity and facilitate storage and dissolution; the solvent is physiological saline to reduce irritation during injection.

- Key Standards: Purity exceeds 99%, free from bacterial and viral contamination, with minimal allergic reactions; molecular weight approximately 150 kDa, structurally stable, and with guaranteed safety.

- Storage Conditions: Undissolved lyophilized powder should be refrigerated at 2-8℃. Freezing, exposure to direct sunlight, and high temperatures are strictly prohibited. Use within 4 hours of dissolving; refrigeration can extend this to 24 hours. Unopened shelf life is approximately 24 months; cold chain transportation is required.

- Administration Method: Primarily administered via subcutaneous or intramuscular injection, adjusting the injection depth according to the site; dissolve with the provided solvent before use, and inject slowly in small, multiple doses to avoid discomfort or toxin spread.

Botox's main function is to block the transmission of contraction signals from nerves to muscles, allowing muscles to relax. It also relieves neurogenic pain and is primarily used in the medical and cosmetic fields:

1. Medical Treatment:

Relieves muscle spasms, treating conditions such as blepharospasm, hemifacial spasm, and spasmodic torticollis, improving muscle twitching and stiffness.

Reduces pain, preventing and relieving migraines and tension headaches, and also alleviating neck, shoulder, and back pain caused by muscle tension.

Other uses include correcting strabismus, reducing excessive sweating in areas such as the armpits and palms, and relieving urinary frequency and urgency caused by overactive bladder.

2. Medical Aesthetics:

Wrinkle removal and anti-aging, targeting dynamic wrinkles such as frown lines, forehead wrinkles, and crow's feet, relaxing facial muscles, diminishing wrinkles, and delaying skin aging.

Facial sculpting, by relaxing the masseter, trapezius, and gastrocnemius muscles, achieving slimmer face, shoulders, and calves without surgery.

- Improves skin texture, reduces skin wrinkles caused by muscle contraction, resulting in smoother, firmer skin, and helps improve enlarged pores.

1. Reliable Efficacy: Advanced purification technology ensures high toxin purity and strong activity. Effects are visible 1-7 days after injection. Its wrinkle-reducing and spasm-relieving effects have been clinically validated over a long period and are recognized by the global medical community.

2. High Safety: Highly targeted, acting only on the muscles at the injection site, without affecting surrounding tissues and nerves. Allergic reactions are extremely rare, making it safer than other botulinum toxins.

3. Convenient Operation: No surgery required. Local anesthesia can be applied as needed. Each injection takes only 10-20 minutes, leaving no obvious wounds and not affecting normal work or life.

4. Wide Applicability: Suitable for both medical and cosmetic uses, it can be used to treat various conditions and for anti-aging and body shaping, suitable for people of different ages and needs.

5. Brand Reliability: As the world's first cosmetic botulinum toxin, it is manufactured by Allergan, certified by authoritative institutions in multiple countries, with strict manufacturing processes, a good reputation, and widespread use in reputable hospitals and cosmetic clinics.

1. Short-lasting effects: Cosmetic effects last 3-8 months, medical effects last 4-6 months, requiring regular repeat injections; long-term injections may lead to muscle atrophy, weakened efficacy, and some individuals may develop antibodies.

2. Adverse reactions: Short-term side effects may include pain, redness, swelling, bruising at the injection site, or mild discomfort such as headache and fatigue, usually subsiding within 1-2 weeks; improper injection may lead to problems such as drooping eyelids, facial stiffness, and in severe cases, poisoning.

3. High usage requirements: It is a prescription drug and cannot be purchased or administered by oneself. It must be administered by a professional doctor in a reputable institution. The doctor must be familiar with muscle and nerve structure; otherwise, risks may arise.

4. Limited Applicable Population: Contraindicated for those allergic to the ingredients, patients with active tumors, pregnant women, breastfeeding women, and children under 12 years old; individuals with diabetes, hypertension, or impaired liver or kidney function should use with caution.

5. High Price: As an imported product, the manufacturing process is complex, resulting in a higher price. Cosmetic treatments are charged per area, while medical treatments require long-term injections, leading to a heavy financial burden with long-term use. Furthermore, counterfeit products exist on the market, posing safety risks.

1. Medical Treatment:
- Neuromuscular diseases, such as blepharospasm, hemifacial spasm, spasmodic torticollis, strabismus, etc., relieving symptoms of abnormal muscle contraction.

- Pain management, used for the prevention and relief of migraines and tension headaches, and as an adjunct treatment for neck, shoulder, and back pain.

- Other conditions, such as primary hyperhidrosis, overactive bladder, facial tics, etc.

2. Medical Aesthetics:
- Wrinkle removal and anti-aging, suitable for individuals aged 25-55 with no severe skin laxity and dynamic wrinkles such as frown lines and forehead wrinkles.

- Facial sculpting: Suitable for individuals with prominent masseter muscles, enlarged trapezius muscles, or thick calves who desire a natural sculpting effect.

- Skin texture improvement: Suitable for individuals with skin wrinkles and enlarged pores due to muscle contraction; can be combined with other cosmetic procedures to enhance results.

3. Other applications: Post-operatively, it helps relieve muscle spasms and accelerate recovery; it improves facial asymmetry caused by unilateral muscle overdevelopment.

1. Proper Procedure: Strictly follow the doctor's instructions. Do not adjust the dosage, injection site, or interval yourself. The procedure must be performed by a professional doctor in a reputable institution. Self-injection by non-professionals or at home is strictly prohibited.

2. Contraindications: This product is contraindicated for certain groups. Individuals requiring caution should inform their doctor of their medical history, medication history, and pregnancy plans beforehand for assessment of suitability.

3. Pre- and Post-operative Care: Avoid using aspirin, gentamicin, and other similar medications for two weeks prior to injection; do not wear makeup on the day of injection and keep the injection site clean; avoid water, makeup, pressure, and hot compresses for 24 hours after injection, and avoid strenuous exercise; avoid excessive facial activity, saunas, and spicy foods for three days; require 30 minutes of observation in the hospital after injection, and be prepared for emergency treatment.

4. Special Populations: Not for use in children under 12 years of age; adolescents aged 12-18 may only use this medication for medical purposes after a doctor's evaluation; elderly individuals should use a reduced dosage and closely monitor for reactions; diabetic patients need to closely monitor their blood glucose levels; athletes should inform their doctor of their occupation in advance; those planning to conceive within the past six months should avoid injection.

5. Storage and Usage Details: Store and transport strictly according to refrigeration requirements, avoiding freezing, exposure to sunlight, and high temperatures; dissolve temporarily before use, shake gently, and use within 4 hours; rotate injection sites regularly, precisely control the injection depth, and avoid injection into blood vessels or nerves.

6. Management of Adverse Reactions: Mild discomfort usually resolves on its own; persistent discomfort requires immediate medical attention. If drooping eyelids or facial stiffness occur, wait for the medication to wear off or seek medical intervention. If severe symptoms such as difficulty breathing or blurred vision occur, discontinue use immediately and seek emergency medical attention. Allergy risk should be assessed by a doctor before each injection.

7. Other Precautions: Effects gradually appear 1-7 days after injection, reaching optimal results in 1-2 weeks; no anxiety is necessary. Avoid frequent massage of the injection site during the maintenance period. Avoid concurrent use with certain medications. Do not use counterfeit products of unknown origin.

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